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ラクトフェリンに関連した学術論文を選抜して紹介します。選抜の基準は次のとおりです。
(1) 本研究会の関係者による学術論文
(2) ラクトフェリンに関する注目すべき学術論文

I．ラクトフェリンは血液−脳関門を越え脳脊髄液に出現する

1. E. Harada, A. Sugiyama, T. Takeuchi, K. Sitizyo, T. Yajima and T. Kuwata.
Characteristic transfer of colostral components into cerebrospinal fluid via serum in neonatal pigs, Biol. Neonate 76: (1999) 33-43
2. C Fillebeen, Descamps L, Dehouck MP, Ferart L, Benaissa M, Spik G and Cecchelli. Receptpr-mediated transcytosis of lactoferrin through the blood-brain barrier. J Biol Chem. 274 (1999) 7011-7017
3. Harada, E. et al.
Characteristic transport of lactoferrin from the intestinal lumen into the bile via the blood in piglets. Comp. Biol. Phsol. 124A: 321-327 (1999)
4. E. Harada, A. Araki, E. Furumura, T. Takeuchi, K. Sitizyo, T. Yajima and T. Kuwata
Characteristic transfer of colostrums-derived biologically active substances into cerebrospinal fluid via blood in natural suckling neonate pigs. J. Vet. Med. A 49 (2002) 358-365
5. M.J.R Talukder, T. Takeuchi and E. Harada.
Transport of colostral macromolecules into the cerebrospinal fluid via plasma in new born calves. J. Dairy Sci. 85 (2002) 514-524.
6. Talukder. M.J.R. et al.
Characteristics of lactoferrin receptors in bovine intestine: higher binding activity to the epithelium overlying Peyer's patch. .J. Vet. Med. A50: (2003) 123-131
7. M.J.R Talukder, T. Takeuchi and E. Harada.
Recptor-mediated transport of lactoferrin into cerebrospinal fluid via plasma in young calves. J. Vet. Med. Sci. 65 (2003) 957-964
8. Kitagawa. H. et al.
Persorption of bovine lactoferrin from the intestinal lumen into the systemic circulation via the portal vein and mesenteric lymphatics in growing pigs. J. Vet. Med. Sci. 65.(2003) 567-572
9. Takeuchi T, Kitagawa H and Harada E.
Evidence of lactoferrin transportation into blood circulation from intestine via lymphatic pathway in adult rats. Exp Physiol. 89 (2004):263-70.


II．ラクトフェリンはオピオイドの作用を増幅する

1. .K. Hayashida, T. Takeuchi, H. Shimizu, K. Ando and E. Harada.
Novel function of bovine milk-derived lactoferrin on antinociception mediated by -opioidreceptor in the rat spinal cord. Brain Res. 965 (2003) 239-245
2. K. Hayashida, T. Takeuchi, H. Shimizu, K. Ando and E. Harada.
Lactoferrin enhances opioid-mediated analgesia via nitric oxide in the rat spinal cord. Am. J. Physiol. 285: (2003) R306-R312
3. T. Takeuchi, K. Hayashida, H. Inagaki, M. Kuwahara, H. Tsubone, E. Harada.
Opioid mediated suppressive effect of milk-derived lactoferrin on distress induced by maternal separation in rat pups. Brain Res. 979 (2003) 216-224
4. T. Takeuchi, M. Iwanaga and E. Harada.
Possible regulatory mechanism of DHA-induced anti-stress reaction in rats.
Brain Res. 964 (2003) 136-143
5. N. Kamemori, T. Takeuchi, K. Hayashida and E. Harada.
Suppressive effects of milk-derived lactoferrin on psychological stress in adult rats.
Brain Res. 1029 (2004) 34-40
6. Hayashida K, Takeuchi T and Harada E.
.Lactoferrin enhances peripheral opioid-mediated antinociception via nitric oxide in rats. Eur J Pharmacol. 484 (2004):175-81.
7. Hayashida K, Takeuchi T, Ozaki T, Shimizu H, Ando K, Miyamoto A and Harada E. Bovine lactoferrin has a nitric oxide-dependent hypotensive effect in rats.
Am J Physiol Regul Integr Comp Physiol. 286 (2004):R359-65.


III．ラクトフェリンはコレステロール異化作用を亢進する

1. Takeuchi. T. et al..
Bovine lactoferrin reduces plasma triacylglycerol and NEFA accompanied by decrease hepatic cholesterol and triglyceride contents in rodents. Br. J. Nutr. 91: (2004) 1-7


IV．ラクトフェリンの抗炎症作用

1. OM Conneely. Antiinflammatory activities of lactoferrin. J Am Coll Nutr. 20 (2001, Suppl 5) 389S-397S. Review
2. C Guillen, McInnes IB, Vaughan D, Speekenbrink AB and Brock JH. The effects of local administration of lactoferrin on inflammation in murine autoimmune and infectious arthritis. Arthritis Rheum. 43 (2000) 2073-2080
3. I Kimber, Cumberbatch M, Dearman RJ, Headon DR, Bhushan M and Griffiths CE. Lactoferrin: influences on Langerhans cells, epidermal cytokines, and cutaneous inflammation. Biochem Cell Biol. 80 (2002) 103-107
4. Troost FJ, Saris WH and Brummer RJ. Recombinant human lactoferrin ingestion attenuates indomethacin-induced enteropathy in vivo in healthy volunteers. Eur J Clin Nutr. 57 (2003) 1579-1585
5. Hayashida K, Kaneko T, Takeuchi T, Shimizu H, Ando K and Harada E. Oral administration of lactoferrin inhibits inflammation and nociception in rat adjuvant-induced arthritis. J. Vet. Med. Sci. 66 (2004) 149-154
6. Togawa J, Nagase H, Tanaka K, Inanari M, Nakajima A, Ueno N. and Saito T. Oral administration of lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance. J Gastroenterol Hepatoll. 17 (2002) 1291-1298.
7. Togawa J, Nagase H, Tanaka K, Imanari M, Umezawa T, Nakajima A, Naito M, Sato S, Saito T. and Sekihara H. Lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance. Am J Physiol Liver physiol. 283 (2002) G187-G195


V．ラクトフェリンの早流産予防効果

1. Y. Sasaki, K. Otsuki, A. Hasegawa, M. Sawada, H. Chiba, M. Negishi, M. Nagata and T. Oki. Preventive effect of recombnant human lactoferrin on lipopolysaccharide-induced preterm delivery in mice. Acta Obstet. Gynecol. Scand. 83 (2004) 1035-1038
2. Y. Mitsuhashi, K. Otsuki, A. Yoda, Y. Shimizu, H. Saito and T. Yanaihara. Effect of lactoferrin on lipopolysaccharide (LPS) induced preterm delivery im mice. Acta Obstet. Gynecol. Scand. 79 (2000) 355-358
3. K. Otsuki, A. Yoda, H. Saito, Y. Mitsuhashi, Y. Tomita, Y. Shimizu and T. Yanaihara. Amniotic fluid lactoferrin in intrauterine infection. Placenta 20 (1999) 175-179
4. K. Otsuki, A. Yoda, Y. Toma, Y. Shimizu, H. Saito and T. Yanaihara. Lactoferrin and interleukin-6 interaction in amniotic infection. Adv. Exp. Med. Biol. 443 (1998) 267-271
5. K. Otsuki, A. Yoda, Y. Mitsuhashi, Y. Shimizu, H. Saito and T. Yanaihara and Y. Makino. Isolation and detection of human lactoferrin binding protein in human amniotic membrane. Lactoferrin; Structure, Function and Applications. Excerpta Medica Intern. Congress Series 1195 (2000), pp343-346
6. H. Saito, K. Otsuki Y. Mitsuhashi, A. Yoda, T. Yanaihara, Y. Shimizu and T. Yanaihara. Role of lactoferrin in the prevention of preterm delivery. Lactoferrin; Structure, Function and Applications. Excerpta Medica Intern. Congress Series 1195 (2000), pp347-352


VI．ラクトフェリンによる真菌の感染防御効果

1. K. Yamauchi et al.; Clinical evaluation of orally administered bovine lactoferrin for treatement of tinea pedis. Lactoferrin; Structure, Function and Applications. Excerpta Medica Intern. Congress Series 1195 (2000), pp377-381
2. 安部茂（帝京大（医）真菌研究センター）
マウス口腔カンジダ症もデルの開発とその応用： Jpn. J. Med. Mycol. 45 (2004) 227-231


VII．ラクトフェリンによるがんのchemoprevention

1. K Sekine, Watanabe E, Nakamura J, Takasuka N, Kim DJ, Asamoto M, Krutovskikh V, Baba-Toriyama H, Ota T, Moore MA, Masuda M, Sugimoto H, Nishino H, Kakizoe T. and Tsuda H. Inhibition of azoxymethane-initiated colon tumor by bovine lactoferrin administration in F344 rats. Jpn J Cancer Res. 88 (1997) 523-526
2. K Sekine, Ushida Y, Huhara T, Iigo M, Baba-Toriyama H, Moore MA, Murakoshi M, Satomi Y, Nishino H, Kakizoe T and Tsuda H. Inhibition of initiation and early stage of development of aberrant crypt focci and enhanced natural killer activity in male rats administered lactoferrin concomitantly woth azoxymethane. Cancer Lett. 121 (1997) 211-216
3. Y Ushida, Sekine K, Kuhara T, Takasuka N, Iigo and Tsuda H. Inhibitory effects of bovine lactoferrin on intestinal polyposis in the Apc(min) mouse. Cancer Lett. 134 (1998) 141-145
4. Y Ushida, Sekine K, Kuhara T, Takasuka N, Iigo M and Tsuda H. Possible chemopreventive effects of bovine lactoferrin on esophagus and lung carcinogenesis in the rat. Jpn J Cancer Res. 90 (1999) 262-267
5. M Iigo, Kuhara T, Ushida Y, Sekine K, Moore MA and Tsuda H.; Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice. Clin Exp Metasitasis. 17 (1999) 35-40
6. T Tanaka, Kawabata K, Kohno H, Honjo S, Murakami M, Ota T. and Tsuda H.; Chemopreventive effect of bovine lactoferrin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats. Jpn J Cnacer Res. 91 (2000) 25-33
7. H Tsuda, Sekine K, Ushida Y, Kuhara T, Takasuka N, Iigo M, Han BS. and Moore MA. Milk and dairy productsi in cancer prevention: focus on bovine lactoferrin. Mutat. Res. 462 (2000) 227-233
8. C Masuda, Wanibuchi H, Sekine K, Yano Y, Otani S, Kishimoto T. and Tsuda H.; Chemopreventive effects of bovine lactoferrin on N-butyl-N-(4-hidroxybutyl) nitrosamine-induced rat bladder carcinogenesis. Jpn J Cancer Res. 91 (2000) 582-588
9. WP Wang, Iigo M, Sato J, Sekine K, Adachi I. and Tsuda H.; Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin. Jpn J Cancer Res. 91 (2000) 1022-1027
10. H Tsuda, Sekine K, Takasuka N, Toriyama-Baba H. and Iigo M.; Prevention of colon carcinogenesis and carcinoma metastasis by orally administered bovine lactofriin in animals. Biofactors 12 (2000) 83-88
11. T Kuhara, Iigo M, Itoh T, ushida Y, Sekine K, Terada N, Okamura H. and Tsuda H.; Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium. Nutr. Cancer 38 (2000) 192-199
12. H Tsuda, Sekine K, Fujita K. and Iigo M.; Cancer prevention by bovine lactoferrin and underlying mechanisms-a review of experimental and clinical studies. Biochem Cell Biol. 80 (2002) 131-136
13. K Fujita, Ohnishi T, Sekine K, Iigo M. and Tsuda H.; Down-regulation of 2-amino-3,8-dimethylimidazzo{4,5-f}quinoxaline (MeIQx)-induced CYP1A2 expression is associated with bovine lactoferrin inhibition of MeIQx-induced liver and colon carcinogenesis in rats. Jpn J Cancer Res. 93 (2002) 616-625
14. M Iigo, Shimamura M, Matsuda E, Fujita K, Nomoto H, Satoh J, Kojima S, Alexander DB, Moore MA. and Tsuda H.; Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis. Cytokine 25 (2004) 36-44
15. K Fujita, Matsuda E, Sekine K, Iigo M. and Tsuda H.; Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat. Cancer Lett. 15 (2004) 21-29
16. K Fujita, Matsuda E, Sekine K, Iigo M. and Tsuda h.; Lactoferrin enhances Fas expression and apotosis in the colon mucosa of azoxymethane-treated rats. Carcinogenesis 25 (2004) 1961-1966
17. M Shimamura, Yamamoto Y, Ashino H, Oikawa T, Hazato T, Tsuda H. and Iigo M.; Bovine lactoferrin inhibits tumor-induced angiogenesis. Int. J Cancer 10 (2004) 111-116
18. H. Tsuda et al. Cancer prevention by natural compounds. Drug Metab. Pharmacokin. 19 (2004) 245-263


VIII．ラクトフェリンによるヘリコバクターの除菌

1. EJ Dial and Lichtenberger LM. Effect of lactoferrin on Helicobacter felis induced gastritis. Biochem Cell Biol. 80(2002):113-117.
2. F. DiMarco et al.; Use of lactoferrin for Helicobacter pylori eradication. Preliminary results. J. Clin. Gastroenterol. 36 (2003) 396-398
3. F. DiMarco et al.: Use of lactoferrin for Helicobacter pylori eradication. Dig. Liver Disease. 35 (2003) 691-693
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